Ukusetshenziswa kwe-iron dextran njengesithasiselo se-iron ekufuyweni kwezingulube ezinkulu, i-Iron dextran iyisithako sensimbi esijovwayo esivame ukusetshenziswa embonini yezingulube ukuvimbela noma ukwelapha i-anemia yokuntuleka kwe-iron kumaphuphu ezingulube.I-ayoni iyisakhi esibalulekile ezingulubeni njengoba isiza ukwakha i-hemoglobin, iphrotheni ethwala umoya-mpilo egazini.Amapulazi ezingulube ezinkulu ngokuvamile asebenzisa i-iron dextran njengesinyathelo sokuvimbela ukuze kuqinisekiswe ukuthi izingulube zinezinga elanele lensimbi ukusekela ukukhula nokuthuthuka.I-Iron dextran ivamise ukulawulwa ngomjovo entanyeni noma ethangeni lamachwane.Umthamo kanye nemvamisa kuzoncika eminyakeni kanye nesisindo samaphuphu.Ukubonisana nodokotela wezilwane noma isazi sokudla kwezilwane kuyanconywa ukuze kunqunywe ukusetshenziswa okufanele kwezithako zensimbi emapulazini ezingulube, njengoba ukusetshenziswa okungalungile kungaholela ezinkingeni zempilo noma ukwehla kokukhiqiza.